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Recent Activity. Andrea E. Affiliations 1. Find all citations in this journal default. Or filter your current search. Frontiers in Molecular Neuroscience [01 Jan , ]. Abstract Stress is well-known to contribute to the development of both neurological and psychiatric diseases.

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While the role of the blood-brain barrier is increasingly recognized in the development of neurodegenerative disorders, such as Alzheimer's disease, dysfunction of the blood-brain barrier has been linked to stress-related psychiatric diseases only recently.

In the present study the effects of restraint stress with different duration 1, 3, and 21 days were investigated on the morphology of the blood-brain barrier in male adult Wistar rats.

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Frontal cortex and hippocampus sections were immunostained for markers of brain endothelial cells claudin-5, occluding, and glucose transporter-1 and astroglia GFAP.

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